Embelin solubility
WebJul 18, 2012 · Embelin, identified primarily from the Embelia ribes plant, has been shown to be a natural small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP). It is also a potent inhibitor of NF-κB activation, which makes it a potentially effective suppressor of tumor cell survival, proliferation, invasion, angiogenesis, and inflammation. WebEmbelin (2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione ); ≥ 98% HPLC, powder; Embelin is an inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein); in vivo antitumor and anti-inflammatory activity; ... solubility. DMSO: >10 mg/mL H 2 O: insoluble. antibiotic …
Embelin solubility
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WebMar 1, 2024 · Embelin represses the expression of phosphorylated NF-κB p65 through the ser536 site in vivo and in vitro. ... Therefore, we aim to optimize the preparation of embelin to solve the problems of low solubility, low bioavailability, and inappropriate dosage in septic AKI treatment. WebOct 8, 2015 · Additionally, Embelin has been found to display antibacterial potential against 3 strains of 12 bacteria. Other studies have reported Embelin to have apoptosis …
WebSolubility Embelin soluble in organic solvent like Dimethylsulphoxide (DMSO), chloroform, alcohol and insoluble in water. Pharmacokinetic ... WebEmbelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high …
WebJul 14, 2010 · Water solubility of embelin was improved from 3 to 42 μg/mL in the prepared complex. n-Octanol solubility were also altered for free embelin and EPC … WebSolubility: ≥ 2.5 mg/mL (8.49 mM); Clear solution 2. BIOLOGICAL ACTIVITY Description Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to
WebEmbelin, a natural benzoquinone from plants of the genus Embelia, is an inhibitor of X-linked inhibitor of apoptosis protein (XIAP) with IC50 of 4.1 μM.XIAP is a member of the inhibitor of apoptosis family of proteins. This …
WebNov 5, 2024 · The drug loaded in SNEDDS consistently takes action on the target without any food effects and rapidly releases the drug onto the specific target site. 13 However, SNEDDS requires a much greater amount of lipidic excipients to solubilize drug depending on its solubility. jea-uaeWebEmbelin is the only known non-peptide small-molecule X-linked inhibitor of the apoptosis protein (XIAP) - an anti-apoptotic protein considered a promising cancer therapeutic … je auditWebAs analyzed by isobologram analysis the combination of bicalutamide and embelin was synergistic for C4-2 but additive and slightly antagonistic for LNCaP cells. Micellar formulation resulted in at least 60-fold increase in the … je audio vl10.1WebEmbelin from the Japanese Ardisia herb is a small-molecular inhibitor that binds to the XIAP BIR3 domain with which Smac and caspsase-9 bind. Embelin inhibits cell growth of both … jeaufixWebMay 20, 2014 · The solubility of EBN in distilled water, Capryol 90, Propylene glycol, PEG 400, Tween 80 and Span 80 determined in these studies are shown in Table 1. Solubility of Embelin in Distilled water was found to be 0.024 mg/g. The saturation solubility of EBN increases in the order of Span 80 < Propylene glycol < Tween 80 < PEG 400 < Capryol 90. jeaudine hillWebFeb 25, 2024 · Fig. 1 Embelin protects the kidney from LPS induced AKI. A) Embelin chemical formula. B) The levels of BUN and Scr in mice after LPS injection in vivo (n = 6 per group). **p < 0.01 compared with the control group; ##p < … je audioWebJan 1, 2014 · Embelin, a chemical constituent obtained from Embelia ribes Burm. Having several therapeutic activities like anthelmintic, antimicrobial, enzyme inhibitory, … la divisa 900 san bernardo