Web13 apr. 2024 · Blood Cancer Journal - Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1 Skip to main content Thank you for visiting nature.com. WebNPM1, a nuclear shuttle factor, resides mainly in the nucleolus and consists of an N-terminal oligomerization domain (OligoD), a central histone-binding domain (HistonD), and a C-terminal nucleic acid-binding domain (NBD) [ 30, 31 ]. NPM1 has been shown to interact with the Rev protein of HIV-1 [ 32] and adenoviral core proteins [ 33 ].
Poor prognosis of nucleophosmin overexpression in solid tumors…
WebThe nucleolus has emerged as a platform for the organization of chromatin enriched for repressive histone modifications associated with repetitive DNA. NPM1 is a nucleolar protein required for the maintenance of genome stability. However, the role of NPM1 in nucleolar chromatin dynamics and ribosome biogenesis remains unclear. Web31 aug. 2024 · The epigenetic process safeguards cell identity during cell division through the inheritance of appropriate gene expression profiles. We demonstrated previously that parental nucleosomes are inherited by the same chromatin domains during DNA replication only in the case of repressed chromatin. We now show that this specificity is conveyed … rtl boulevard boos
NPM1 histone chaperone is upregulated in glioblastoma to …
WebNPM1 exhibited remarkable linker histone H1 chaperone activity, as it was able to efficiently deposit histone H1 onto dinucleosomal templates. Overexpression of NPM1 reduced the histone H1 occupancy on the chromatinized template of HIV-1 LTR in TZM-bl cells, which led to enhanced Tat-mediated transactivation. Web2 okt. 2006 · The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling protein that is localized mainly in the nucleolus.NPM1 mutations occur in 50% to 60% of adult acute myeloid leukemia with normal karyotype (AML-NK) and generate NPM mutants that localize aberrantly in the leukemic-cell cytoplasm, hence the … Web21 mrt. 2024 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Aml With Myelodysplasia-Related Features and Leukemia, Acute … rtl boulevard intro